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The Big Hole River is a tributary of the Jefferson River, approximately 153 miles (246 km) long, in southwestern Montana in the United States. It rises in Skinner lake in the Beaverhead National Forest in the Beaverhead Mountains of the Bitterroot Range at the continental divide along the Montana-Idaho border in western Beaverhead County. It flows northwest and north, past Wisdom and between the Anaconda Range to the northwest and the Pioneer Mountains to the east. It flows around the north end of the Pioneer Mountains, then southeast, past the town of Wise River, Montana, where it is joined by the Wise River. Near Glen, Montana it turns northeast and joins the Beaverhead river near Twin Bridges to form the Jefferson.